Inhibition of MEK sensitizes human melanoma cells to endoplasmic reticulum stress-induced apoptosis.

@article{Jiang2007InhibitionOM,
  title={Inhibition of MEK sensitizes human melanoma cells to endoplasmic reticulum stress-induced apoptosis.},
  author={Chen Chen Jiang and Li Hua Chen and Susan K.H. Gillespie and Yu Wang and Kelly Anne Kiejda and Peter Hersey},
  journal={Cancer research},
  year={2007},
  volume={67 20},
  pages={
          9750-61
        }
}

• Chen Chen Jiang, Li Hua Chen, +3 authors Peter Hersey
• Published in Cancer research 2007

Past studies have shown that activation of mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK is a common cause for resistance of melanoma cells to death receptor-mediated or mitochondria-mediated apoptosis. We report in this study that inhibition of the MEK/ERK pathway also sensitizes melanoma cells to endoplasmic reticulum (ER) stress-induced apoptosis, and this is mediated, at least in part, by caspase-4 activation and is associated with inhibition… CONTINUE READING

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