Inhibition of MAPK signaling by eNOS gene transfer improves ventricular remodeling after myocardial infarction through reduction of inflammation

@article{Chen2009InhibitionOM,
  title={Inhibition of MAPK signaling by eNOS gene transfer improves ventricular remodeling after myocardial infarction through reduction of inflammation},
  author={Lei-lei Chen and Tie Bin Zhu and Hang Yin and Jun Huang and Lian Sheng Wang and Ke Cao and Zhi Jian Yang},
  journal={Molecular Biology Reports},
  year={2009},
  volume={37},
  pages={3067-3072}
}
Endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) may play an important role in attenuating cardiac remodeling and apoptosis after myocardial infarction. However, the anti-inflammation effects of eNOS in infarcted myocardium and the role of MAPK signaling in eNOS/NO mediated cardiac remodeling have not yet been elucidated. Adenovirus carrying Human eNOS gene was delivered locally into heart 4 days prior to induction of myocardial infarction (MI) by left anterior descending coronary… CONTINUE READING

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