Inhibition of MAPK/ERK signaling blocks hippocampal neurogenesis and impairs cognitive performance in prenatally infected neonatal rats

@article{Jiang2015InhibitionOM,
  title={Inhibition of MAPK/ERK signaling blocks hippocampal neurogenesis and impairs cognitive performance in prenatally infected neonatal rats},
  author={Peifang Jiang and Tao Zhu and Zhezhi Xia and Feng Gao and W. F. Gu and Xin Chen and Tianming Yuan and Huimin Yu},
  journal={European Archives of Psychiatry and Clinical Neuroscience},
  year={2015},
  volume={265},
  pages={497-509}
}
Hippocampus endogenous neurogenesis has been postulated to play a favorable role in brain restoration after injury. However, the underlying molecular mechanisms have been insufficiently deciphered. Here we investigated the potential regulatory capacity of MAPK/ERK signaling on neurogenesis and the associated cognitive performance in prenatally infected neonatal rats. From our data, intrauterine infection could induce hippocampal neuronal apoptosis and promote endogenous repair by evoking neural… CONTINUE READING