Inhibition of MAO and GABA: probable mechanisms for antidepressant-like activity of Nardostachys jatamansi DC. in mice.
@article{Dhingra2008InhibitionOM, title={Inhibition of MAO and GABA: probable mechanisms for antidepressant-like activity of Nardostachys jatamansi DC. in mice.}, author={Dinesh Dhingra and Parveen Goyal}, journal={Indian journal of experimental biology}, year={2008}, volume={46 4}, pages={ 212-8 } }
Ethanolic extract (100, 200 and 400 mg/kg, po) of N. jatamansi administered for 14 successive days to Swiss young albino mice (either sex) produced significant antidepressant-like effect in both tail suspension and forced swim tests. The efficacy of the extract was found to be comparable to imipramine (15 mg/kg, po) and sertraline (20 mg/kg, po). Ethanolic extract (200 mg/kg, po) did not show any significant change on locomotor activity of mice as compared to control; hence it did not produce…
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References
SHOWING 1-10 OF 41 REFERENCES
Antidepressant-like activity of Glycyrrhiza glabra L. in mouse models of immobility tests
- Biology, PsychologyProgress in Neuro-Psychopharmacology and Biological Psychiatry
- 2006
Antidepressant-like effect of icariin and its possible mechanism in mice
- Biology, PsychologyPharmacology Biochemistry and Behavior
- 2005
Antidepressant activity of aqueous extracts of Curcuma longa in mice.
- Biology, PsychologyJournal of ethnopharmacology
- 2002
Putrescine produces antidepressant-like effects in the forced swimming test and in the tail suspension test in mice
- Biology, PsychologyProgress in Neuro-Psychopharmacology and Biological Psychiatry
- 2006
Effects of Nardostachys jatamansi on biogenic amines and inhibitory amino acids in the rat brain.
- BiologyPlanta medica
- 1994
The data indicate that the alcoholic extract of the roots of N. jatamansi causes an overall increase in the levels of central monoamines and inhibitory amino acids.
Attenuation by Nardostachys jatamansi of 6-hydroxydopamine-induced parkinsonism in rats: behavioral, neurochemical, and immunohistochemical studies
- BiologyPharmacology Biochemistry and Behavior
- 2006
Anticonvulsant and neurotoxicity profile of Nardostachys jatamansi in rats.
- BiologyJournal of ethnopharmacology
- 2005
Involvement of GABAB receptor systems in experimental depression: baclofen but not bicuculline exacerbates helplessness in rats
- Psychology, BiologyBrain Research
- 1996
Nardostachys jatamansi improves learning and memory in mice.
- Biology, PsychologyJournal of medicinal food
- 2006
Assessment of the potential of N. jatmansi as a memory enhancer found it to be a useful memory restorative agent in the treatment of dementia seen in elderly persons and the underlying mechanism of action can be attributed to its antioxidant property.
Genetic and Pharmacological Evidence of a Role for GABAB Receptors in the Modulation of Anxiety- and Antidepressant-Like Behavior
- Biology, PsychologyNeuropsychopharmacology
- 2004
Positive modulation of the GABAB receptors may serve as a novel therapeutic strategy for the development of anxiolytics, whereas GABAB receptor antagonism may service as a basis for the generation of novel antidepressants.