• Corpus ID: 12620694

Inhibition of MAO and GABA: probable mechanisms for antidepressant-like activity of Nardostachys jatamansi DC. in mice.

@article{Dhingra2008InhibitionOM,
  title={Inhibition of MAO and GABA: probable mechanisms for antidepressant-like activity of Nardostachys jatamansi DC. in mice.},
  author={Dinesh Dhingra and Parveen Goyal},
  journal={Indian journal of experimental biology},
  year={2008},
  volume={46 4},
  pages={
          212-8
        }
}
  • D. DhingraP. Goyal
  • Published 1 April 2008
  • Biology, Psychology
  • Indian journal of experimental biology
Ethanolic extract (100, 200 and 400 mg/kg, po) of N. jatamansi administered for 14 successive days to Swiss young albino mice (either sex) produced significant antidepressant-like effect in both tail suspension and forced swim tests. The efficacy of the extract was found to be comparable to imipramine (15 mg/kg, po) and sertraline (20 mg/kg, po). Ethanolic extract (200 mg/kg, po) did not show any significant change on locomotor activity of mice as compared to control; hence it did not produce… 

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