Inhibition of Leptin-ObR Interaction Does not Prevent Leptin Translocation Across a Human Blood-Brain Barrier Model.

@article{GonzalezCarter2016InhibitionOL,
  title={Inhibition of Leptin-ObR Interaction Does not Prevent Leptin Translocation Across a Human Blood-Brain Barrier Model.},
  author={D Gonzalez-Carter and Angela Erin Goode and Roberto Fiammengo and Iain E Dunlop and David T Dexter and Alexandra E. Porter},
  journal={Journal of neuroendocrinology},
  year={2016},
  volume={28 6}
}
The adipocyte-derived hormone leptin regulates appetite and energy homeostasis through the activation of leptin receptors (ObR) on hypothalamic neurones; hence, leptin must be transported through the blood-brain barrier (BBB) to reach its target sites in the central nervous system. During obesity, however, leptin BBB transport is decreased, in part precluding leptin as a viable clinical therapy against obesity. Although the short isoform of the ObR (ObRa) has been implicated in the transport of… CONTINUE READING

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