Inhibition of Lassa Virus Glycoprotein Cleavage and Multicycle Replication by Site 1 Protease-Adapted α1-Antitrypsin Variants

@article{Maisa2009InhibitionOL,
  title={Inhibition of Lassa Virus Glycoprotein Cleavage and Multicycle Replication by Site 1 Protease-Adapted α1-Antitrypsin Variants},
  author={Anna Maisa and Ute Stroeher and H -D Klenk and Wolfgang Garten and Thomas Strecker},
  journal={PLoS Neglected Tropical Diseases},
  year={2009},
  volume={3},
  pages={75 - 109}
}
BACKGROUND Proteolytic processing of the Lassa virus envelope glycoprotein precursor GP-C by the host proprotein convertase site 1 protease (S1P) is a prerequisite for the incorporation of the subunits GP-1 and GP-2 into viral particles and, hence, essential for infectivity and virus spread. Therefore, we tested in this study the concept of using S1P as a target to block efficient virus replication. METHODOLOGY/PRINCIPAL FINDING We demonstrate that stable cell lines inducibly expressing S1P… CONTINUE READING
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