Inhibition of LTB4 biosynthesis in situ by CGS 23885, a potent 5-lipoxygenase inhibitor, correlates with its pleural fluid concentrations in an experimentally induced rat pleurisy model

@article{Raychaudhuri1997InhibitionOL,
  title={Inhibition of LTB4 biosynthesis in situ by CGS 23885, a potent 5-lipoxygenase inhibitor, correlates with its pleural fluid concentrations in an experimentally induced rat pleurisy model},
  author={Anilbaran Raychaudhuri and Herbert Chertock and James P. Chovan and L S Jones and Earl F. Kimble and Timothy J. Kowalski and Jane V. Peppard and David H. White and Yoshitaka Satoh and Dennis M. Roland},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1997},
  volume={355},
  pages={470-474}
}
Abstract An intrapleural injection of carrageenan in rats induced LTB4 and LTC4/D4/E4 biosynthesis, exudate formation, and cellular influx in the pleural cavity. An injection of calcium ionophore (A23187, 100nmol) 16–18h after carrageenan injection augmented leukotriene biosynthesis and exudate formation, but not cellular influx. The carrageenan-induced pleurisy model modifid by A23187 administration was used to study the oral effect of CGS 23885 (N-hydroxy-N-[(6-phenoxy-2H-1-benzopyran-3-yl… 
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7 Citations

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