Inhibition of LPS-stimulated pathways in macrophages by the flavonoid luteolin.

@article{Xagorari2002InhibitionOL,
  title={Inhibition of LPS-stimulated pathways in macrophages by the flavonoid luteolin.},
  author={Angeliki Xagorari and Charis Roussos and Andreas Papapetropoulos},
  journal={British journal of pharmacology},
  year={2002},
  volume={136 7},
  pages={
          1058-64
        }
}
1: We have previously shown that the flavonoid luteolin inhibits the expression of pro-inflammatory molecules induced by LPS. In the present study we tested the ability of luteolin to block signalling pathways implicated in LPS-induced inflammatory gene expression in macrophages. 2: Exposure of the murine macrophage cell line RAW 264.7 to LPS increased phosphorylation of the mitogen-activated protein kinase family members ERK1/2, p38 and JNK1/2 in a time-dependent manner. Pretreatment of RAW… CONTINUE READING
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