Inhibition of LPS-induced NO and PGE2 production by asiatic acid via NF-kappa B inactivation in RAW 264.7 macrophages: possible involvement of the IKK and MAPK pathways.

@article{Yun2008InhibitionOL,
  title={Inhibition of LPS-induced NO and PGE2 production by asiatic acid via NF-kappa B inactivation in RAW 264.7 macrophages: possible involvement of the IKK and MAPK pathways.},
  author={Kyung-Jin Yun and Ji-Yeon Kim and Jong-Bin Kim and Kyung-won Lee and Seo-Young Jeong and H Park and Hyun-Ju Jung and Y W Cho and Kijoo Yun and K. -J. Lee},
  journal={International immunopharmacology},
  year={2008},
  volume={8 3},
  pages={431-41}
}
In the present study, we investigated the effect of asiatic acid (the aglycon of asiaticoside) and asiaticoside isolated from the leaves of Centella asiatica (Umbelliferae) on LPS-induced NO and PGE(2) production in RAW 264.7 macrophage cells. Asiatic acid more potently inhibited LPS-induced NO and PGE(2) production than asiaticoside. Consistent with these observations, the protein and mRNA expression levels of inducible iNOS and COX-2 enzymes were inhibited by asiatic acid in a concentration… CONTINUE READING

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