Inhibition of LPL expression in human monocyte-derived macrophages is dependent on LDL oxidation state: a key role for lysophosphatidylcholine.

@article{Stengel1998InhibitionOL,
  title={Inhibition of LPL expression in human monocyte-derived macrophages is dependent on LDL oxidation state: a key role for lysophosphatidylcholine.},
  author={Dominique Stengel and M. Antonucci and W Gaoua and Christiane Dachet and Philippe Lesnik and Delphine Hourton and Ewa Ninio and Martin John Chapman and Sabine Griglio},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1998},
  volume={18 7},
  pages={1172-80}
}
The regulation of macrophage lipoprotein lipase (LPL) secretion and mRNA expression by atherogenic lipoproteins is of critical relevance to foam cell formation. LPL is present in arterial lesions and constitutes a bridging ligand between lipoproteins, proteoglycans, and cell receptors, thus favoring macrophage lipoprotein uptake and lipid accumulation. We investigated the effects of native and of oxidized lipoproteins on the expression of LPL in an in vitro human monocyte-macrophage system… CONTINUE READING

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Physiological regulation of lipoprotein lipase.

Biochimica et biophysica acta • 2014
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