Inhibition of L-leucine methyl ester mediated killing of THP-1, a human monocytic cell line, by a new anti-inflammatory drug, T614.

@article{Sawada2000InhibitionOL,
  title={Inhibition of L-leucine methyl ester mediated killing of THP-1, a human monocytic cell line, by a new anti-inflammatory drug, T614.},
  author={T. Sawada and S. Hashimoto and S. Tohma and Y. Nishioka and T. Nagai and T. Sato and K. Ito and T. Inoue and M. Iwata and K. Yamamoto},
  journal={Immunopharmacology},
  year={2000},
  volume={49 3},
  pages={
          285-94
        }
}
T614 (3-formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-o ne) is a member of the family of methanesulfonanilide non-steroidal anti-inflammatory drugs (mNSAIDs), most of which act as cyclooxygenase (COX)-2 inhibitors. L-leucine methyl ester (Leu-OME) is a reagent which has been shown to kill phagocytes following interaction with intracellular proteases. There are two pathways whereby Leu-OME becomes cytotoxic to phagocytes. Within lysosomes, Leu-OME is converted into free Leu… Expand
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