Inhibition of KLF7-Targeting MicroRNA 146b Promotes Sciatic Nerve Regeneration

@article{Li2018InhibitionOK,
  title={Inhibition of KLF7-Targeting MicroRNA 146b Promotes Sciatic Nerve Regeneration},
  author={Wen-yuan Li and Wei-Ting Zhang and Yong-Xia Cheng and Yan-cui Liu and Feng-Guo Zhai and Ping Sun and Hui Li and Lingxiao Deng and Xiaofeng Zhu and Ying Wang},
  journal={Neuroscience Bulletin},
  year={2018},
  volume={34},
  pages={419-437}
}
A previous study has indicated that Krüppel-like factor 7 (KLF7), a transcription factor that stimulates Schwann cell (SC) proliferation and axonal regeneration after peripheral nerve injury, is a promising therapeutic transcription factor in nerve injury. We aimed to identify whether inhibition of microRNA-146b (miR-146b) affected SC proliferation, migration, and myelinated axon regeneration following sciatic nerve injury by regulating its direct target KLF7. SCs were transfected with miRNA… 
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