Inhibition of KCa3.1 suppresses TGF-β1 induced MCP-1 expression in human proximal tubular cells through Smad3, p38 and ERK1/2 signaling pathways.

@article{Huang2014InhibitionOK,
  title={Inhibition of KCa3.1 suppresses TGF-β1 induced MCP-1 expression in human proximal tubular cells through Smad3, p38 and ERK1/2 signaling pathways.},
  author={Chunling Huang and Margot Day and Philip Poronnik and Carol A. Pollock and Xin-Ming Chen},
  journal={The international journal of biochemistry & cell biology},
  year={2014},
  volume={47},
  pages={
          1-10
        }
}
It is well known that TGF-β1 plays a central role in renal fibrosis due in large part to stimulation of inflammatory responses. KCa3.1, a potassium channel protein, has been suggested as a potential therapeutic target for diseases such as sickle cell anemia, autoimmunity, atherosclerosis and more recently, kidney fibrosis. Blockade of KCa3.1 has been shown to ameliorate renal fibrosis in diabetic mice in association with reduced TGF-β1 signaling. However, the centrality of KCa3.1 activation to… CONTINUE READING
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