Inhibition of Junin virus RNA synthesis by an antiviral acridone derivative.

  title={Inhibition of Junin virus RNA synthesis by an antiviral acridone derivative.},
  author={Claudia Soledad Sep{\'u}lveda and Cybele C. Garc{\'i}a and Mirta L. Fascio and Norma Beatriz D'Accorso and Maite L Docampo Palacios and Rolando F Pell{\'o}n and Elsa B Damonte},
  journal={Antiviral research},
  volume={93 1},
There are no specific approved drugs for the treatment of agents of viral hemorrhagic fevers (HF) and antiviral therapies against these viruses are urgently needed. The present study characterizes the potent and selective antiviral activity against the HF causing arenavirus Junin virus (JUNV) of the compound 10-allyl-6-chloro-4-methoxy-9(10H)-acridone, designated 3f. The effectiveness of 3f to inhibit JUNV multiplication was not importantly affected by the initial multiplicity of infection… CONTINUE READING
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