Inhibition of Janus kinase signaling during controlled mechanical ventilation prevents ventilation-induced diaphragm dysfunction

@inproceedings{Smith2014InhibitionOJ,
  title={Inhibition of Janus kinase signaling during controlled mechanical ventilation prevents ventilation-induced diaphragm dysfunction},
  author={Ira J. Smith and Guillermo L. Godinez and Baljit Kaur Surjit Singh and Kelly M. McCaughey and Raniel R. Alcantara and Tarikere L. Gururaja and Melissa S. Ho and Henry N. Nguyen and Annabelle M. Friera and Kathy A White and John R. Mclaughlin and Derek Hansen and J. M. L{\'o}pez Romero and Kristen A. Baltgalvis and Mark D. Claypool and Wei Li and Wayne Terrence Lang and George C. Yam and Marina S. Gelman and Rongxian Ding and Stephanie L. Yung and Daniel P. Creger and Yan Hong Chen and Ramsharan Singh and Ashley J. Smuder and Michael P. Wiggs and Oh-sung Kwon and Kurt J Sollanek and Scott K. Powers and Esteban S. Masuda and Vanessa C. Taylor and Donald G. Payan and Taisei Kinoshita and Todd M. Kinsella},
  booktitle={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2014}
}
Controlled mechanical ventilation (CMV) is associated with the development of diaphragm atrophy and contractile dysfunction, and respiratory muscle weakness is thought to contribute significantly to delayed weaning of patients. Therefore, therapeutic strategies for preventing these processes may have clinical benefit. The aim of the current study was to investigate the role of the Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) signaling pathway in CMV-mediated… CONTINUE READING

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