Inhibition of JNK activation through NF-kappaB target genes.

  title={Inhibition of JNK activation through NF-kappaB target genes.},
  author={Guilin Tang and Yuzuru Minemoto and Benjamin C Dibling and Nicole H. Purcell and Zhiwei Li and Michael Karin and Anning Lin},
  volume={414 6861},
The proinflammatory cytokine tumour necrosis factor-alpha (TNF-alpha) regulates immune responses, inflammation and programmed cell death (apoptosis). The ultimate fate of a cell exposed to TNF-alpha is determined by signal integration between its different effectors, including IkappaB kinase (IKK), c-Jun N-terminal protein kinase (JNK) and caspases. Activation of caspases is required for apoptotic cell death, whereas IKK activation inhibits apoptosis through the transcription factor NF-kappaB… CONTINUE READING
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