Inhibition of JNK activation through NF-κB target genes

  title={Inhibition of JNK activation through NF-κB target genes},
  author={Guilin Tang and Yuzuru Minemoto and Benjamin C Dibling and Nicole H. Purcell and Zhiwei Li and Michael Karin and Anning Lin},
The proinflammatory cytokine tumour necrosis factor-α (TNF-α) regulates immune responses, inflammation and programmed cell death (apoptosis). The ultimate fate of a cell exposed to TNF-α is determined by signal integration between its different effectors, including IκB kinase (IKK), c-Jun N-terminal protein kinase (JNK) and caspases. Activation of caspases is required for apoptotic cell death, whereas IKK activation inhibits apoptosis through the transcription factor NF-κB, whose target genes… CONTINUE READING


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