Inhibition of JAK2/STAT3 signalling induces colorectal cancer cell apoptosis via mitochondrial pathway

@inproceedings{Du2012InhibitionOJ,
  title={Inhibition of JAK2/STAT3 signalling induces colorectal cancer cell apoptosis via mitochondrial pathway},
  author={Wan Tong Du and J. Z. Hong and Ying-chao Wang and Yan-jie Zhang and Ping Wang and Wen-Yu Su and Yan-wei Lin and Rong Lu and Wei-Ping Zou and H. W. Xiong and Jingyuan Fang},
  booktitle={Journal of cellular and molecular medicine},
  year={2012}
}
Abnormalities in the JAK2/STAT3 pathway are involved in the pathogenesis of colorectal cancer (CRC), including apoptosis. However, the exact mechanism by which dysregulated JAK2/STAT3 signalling contributes to the apoptosis has not been clarified. To investigate the role of both JAK2 and STAT3 in the mechanism underlying CRC apoptosis, we inhibited JAK2 with AG490 and depleted STAT3 with a small interfering RNA. Our data showed that inhibition of JAK2/STAT3 signalling induced CRC cellular… CONTINUE READING
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