Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells.

@article{Xiong2008InhibitionOJ,
  title={Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells.},
  author={H. W. Xiong and Zhigang Zhang and Xiao-Qing Tian and Dan-feng Sun and Qin-Chuan Liang and Yan-jie Zhang and Rong Lu and Ying-Xuan Chen and Jingyuan Fang},
  journal={Neoplasia},
  year={2008},
  volume={10 3},
  pages={287-97}
}
Abnormalities in the STAT3 pathway are involved in the oncogenesis of several cancers. However, the mechanism by which dysregulated STAT3 signaling contributes to the progression of human colorectal cancer (CRC) has not been elucidated, nor has the role of JAK, the physiological activator of STAT3, been evaluated. To investigate the role of both JAK and STAT3 in CRC progression, we inhibited JAK with AG490 and depleted STAT3 with a SiRNA. Our results demonstrate that STAT3 and both JAK1 and 2… CONTINUE READING

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