Inhibition of IkappaB kinase by a new class of retinoid-related anticancer agents that induce apoptosis.

@article{Bayon2003InhibitionOI,
  title={Inhibition of IkappaB kinase by a new class of retinoid-related anticancer agents that induce apoptosis.},
  author={Yolanda Bayon and M Angeles Ortiz and Francisco J. L{\'o}pez-Hern{\'a}ndez and Feng Gao and Michael Karin and Magnus Pfahl and Francisco Javier Piedrafita},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 3},
  pages={1061-74}
}
The transcription factor NF-kappaB is overexpressed or constitutively activated in many cancer cells, where it induces expression of antiapoptotic genes correlating with resistance to anticancer therapies. Small molecules that inhibit the NF-kappaB signaling pathway could therefore be used to induce apoptosis in NF-kappaB-overexpressing tumors and potentially serve as anticancer agents. We found that retinoid antagonist MX781 inhibited the activation of NF-kappaB-dependent transcriptional… CONTINUE READING

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Nuclear factor-kappaB p65 (RelA) transcription factor is constitutively activated in human gastric carcinoma tissue.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2001

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