Inhibition of IgE production of mice by non-specific suppressor T cells.


SWR adult normal splenic T lymphocytes injected into irradiated syngeneic mice along with immune spleen cells can suppress IgE formation by the immune cells. Spleen cells from 1- or 3-week-old mice, however, are not effective in abrogating IgE synthesis. The T lymphocytes which are induced to become suppressors for IgE are hydrocortisone-resistant and anti-thymocyte serum-sensitive. Normal SJL mice, a poor reagin-producing strain, do not appear to have more suppressor cells or cells which are more easily stimulated to become suppressor cells than a good reagin-producing strain (SWR).


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@article{Gollapudi1977InhibitionOI, title={Inhibition of IgE production of mice by non-specific suppressor T cells.}, author={Sastry V. R. S. Gollapudi and Lucy Kind}, journal={International archives of allergy and applied immunology}, year={1977}, volume={53 5}, pages={395-401} }