Inhibition of IgE-mediated histamine release from human leukocytes by a new xanthine derivative, D 4026

@article{Petersson2005InhibitionOI,
  title={Inhibition of IgE-mediated histamine release from human leukocytes by a new xanthine derivative, D 4026},
  author={Bengt-{\AA}ke Petersson and I. Svedinger and K. Bohlinder},
  journal={Agents and Actions},
  year={2005},
  volume={10},
  pages={403-410}
}
  • Bengt-Åke Petersson, I. Svedinger, K. Bohlinder
  • Published 2005
  • Chemistry, Medicine
  • Agents and Actions
  • Pretreatment of human leukocytes with the new xanthine compound, 3,7-dihydro-1,8-dimethyl-3-phenyl-1H-purine-2,6-dione (D 4026), induced a dose-dependent and statistically significant inhibition of immunoglobulin E-mediated histamine release in the concentration interval 0·1–1000 μM. Histamine release elicited with suboptimum amounts of the triggering agent (anti-IgE or antigen) was inhibited to a greater extent than a release initiated with optimum amounts. At a concentration of 10 μM, D 4026… CONTINUE READING
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