Inhibition of IL-6 and IL-10 signaling and Stat activation by inflammatory and stress pathways.

@article{Ahmed2000InhibitionOI,
  title={Inhibition of IL-6 and IL-10 signaling and Stat activation by inflammatory and stress pathways.},
  author={Simi T. Ahmed and Lionel B Ivashkiv},
  journal={Journal of immunology},
  year={2000},
  volume={165 9},
  pages={5227-37}
}
The development and resolution of an inflammatory process are regulated by a complex interplay among cytokines that have pro- and anti-inflammatory effects. Effective and sustained action of a proinflammatory cytokine depends on synergy with other inflammatory cytokines and antagonism of opposing cytokines that are often highly expressed at inflammatory sites. We analyzed the effects of the inflammatory and stress agents, IL-1, TNF-alpha, LPS, sorbitol, and H(2)O(2), on signaling by IL-6 and IL… CONTINUE READING

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