Inhibition of IL-12 production in human monocyte-derived macrophages by TNF.

@article{Ma2000InhibitionOI,
  title={Inhibition of IL-12 production in human monocyte-derived macrophages by TNF.},
  author={Xiao Jing Ma and Jiangfeng Sun and Emmanouil Papasavvas and Helge Riemann and Scott Michael Robertson and Jason Marshall and Robert T. Bailer and Anne L. Moore and Raymond P Donnelly and Giorgio Trinchieri and Luis J Montaner},
  journal={Journal of immunology},
  year={2000},
  volume={164 4},
  pages={1722-9}
}
IL-12 is a pivotal cytokine that links the innate and adaptive immune responses. TNF-alpha also plays a key role in orchestrating inflammation and immunity. The reciprocal influence of these two inflammatory mediators on each other may have significant impact on the cytokine balance that shapes the type and extent of immune responses. To investigate the relationship between TNF-alpha and IL-12 production, we analyzed the effects of exposure of human monocyte-derived macrophages to TNF-alpha on… CONTINUE READING

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