Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene.

@article{DAmbrosio1998InhibitionOI,
  title={Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene.},
  author={Daniele D'Ambrosio and Marco Cippitelli and M G Cocciolo and D. Mazzeo and Pietro di Lucia and Richard C Lang and Francesco Sinigaglia and Paola Panina-Bordignon},
  journal={The Journal of clinical investigation},
  year={1998},
  volume={101 1},
  pages={252-62}
}
Interleukin 12 (IL-12), produced by myelomonocytic cells, plays a pivotal role in the development of T helper 1 (Th1) cells, which are involved in the pathogenesis of chronic inflammatory autoimmune disorders. 1,25-Dihydroxyvitamin D3 [1,25(OH)2D3] inhibits IL-12 production by activated macrophages and dendritic cells, thus providing a novel interpretation to its immunosuppressive properties. 1,25(OH)2D3 significantly inhibits mRNA expression for both IL-12 p35 and p40 subunits acting at the… CONTINUE READING