Inhibition of IL-1, IL-6, and TNF-α in immune-mediated inflammatory diseases

  title={Inhibition of IL-1, IL-6, and TNF-α in immune-mediated inflammatory diseases},
  author={Burkhard M{\"o}ller and P Villiger},
  journal={Springer Seminars in Immunopathology},
Blockade of cytokines, particularly of tumour necrosis factor alpha (TNF-α), in immuno-inflammatory diseases, has led to the greatest advances in medicine of recent years. We did a thorough review of the literature with a focus on inflammation models in rodents on modified gene expression or bioactivity for IL-1, IL-6, and TNF-α, and we summarized the results of randomized controlled clinical trials in human disease. What we have learned herewith is that important information can be achieved by… CONTINUE READING
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