Inhibition of IGF-1R and lipoxygenase by nordihydroguaiaretic acid (NDGA) analogs.

@article{Blecha2007InhibitionOI,
  title={Inhibition of IGF-1R and lipoxygenase by nordihydroguaiaretic acid (NDGA) analogs.},
  author={Joseph E. Blecha and Marc O. Anderson and Jennifer M Chow and Christle C. Guevarra and Celia Pender and Cristina Penaranda and Marianna Zavodovskaya and Jack Youngren and Clifford E Berkman},
  journal={Bioorganic \& medicinal chemistry letters},
  year={2007},
  volume={17 14},
  pages={
          4026-9
        }
}
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TLDR
A review of recent findings related to the role of 15- lipoxygenase enzyme and metabolites in breast cancer growth, apoptosis, metastasis, and invasion as well as their local and circulating expression pattern in patients with breast cancer supports the emerging role of the 15-lipoxygenases in molecular and cellular processes regulating breast tumor cell fate with both positive and negative effects.
Nordihydroguaiaretic Acid in Therapeutics: Beneficial to Toxicity Profiles and the Search for its Analogs.
TLDR
Nordihydroguaiaretic acid derivatives should be investigated more in terms of chemical synthesis with preferred conformational structures and exploit their biological potentials with future insights to explore in this direction to design and develop structurally modified NDGA derivatives for potential pharmacological properties.
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References

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TLDR
The studies indicate that the anti-breast cancer properties of NDGA are related to the inhibition of two important RTKs, and agents of this class may provide new insights into potential therapies for this disease.
Differential effects of putative lipoxygenase inhibitors on arachidonic acid metabolism in cell-free and intact cell preparations
TLDR
The results suggest that putative lipoxygenase inhibitors exhibit both qualitative and quantitative differences in their effects on both lip Oxygenases and cyclooxygenases.
Structure-activity relationship of polyphenols that inhibit fatty acid synthase.
TLDR
A common model possibly shared by all FAS polyphenol inhibitors is proposed that includes two almost planar aromatic rings with their respective hydroxyl groups, and a proper ester linkage between the two rings that possibly causes the inhibition of FAS by irreversibly inhibiting the beta-ketoacyl reductase domain.
Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase.
TLDR
The labs have synthesized and investigated nordihydroguaiaretic acid derivatives and established that the reductive inhibition of soybean and 15-human LO can be affected by the strength of the electron-withdrawing substituents on the phenyl rings of NDGA.
Effects of some non-steroidal anti-inflammatory drugs and other agents on cyclooxygenase and lipoxygenase activities in some enzyme preparations.
TLDR
BW755C, phenidone, ethoxyquin, NDGA, APH and dithiol, which strongly inhibited 5-LO, showed an inhibitory activity on the generation of chemiluminescence from PMNs activated with phorbol ester.
Role of IGF-1R in mediating breast cancer invasion and metastasis.
TLDR
It is concluded that disrupting IGF-1R signaling has many important implications in the treatment and management of breast cancer.
Pyrazolo[3,4-c]pyridazines as novel and selective inhibitors of cyclin-dependent kinases.
TLDR
Monofuryl 1o has been synthesized and is one of the most active compounds against CDK1 of this series and has been rationalized on the basis of the proposed binding mode for compound 1a.
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