Inhibition of ICMT induces endothelial cell apoptosis through GRP94.

Abstract

Isoprenylcysteine-O-carboxyl methyltransferase (ICMT) catalyzes methylation of proteins containing a C-terminal CAAX motif. We have previously shown that chemical inhibition of ICMT caused endothelial cell apoptosis, an effect correlated with decreased Ras and RhoA carboxyl methylation and GTPase activities. In the current study, proteomic analysis of… (More)

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@article{Lu2007InhibitionOI, title={Inhibition of ICMT induces endothelial cell apoptosis through GRP94.}, author={Qing Lu and Elizabeth O Harrington and Julie Newton and Matthew Jankowich and Sharon I S Rounds}, journal={American journal of respiratory cell and molecular biology}, year={2007}, volume={37 1}, pages={20-30} }