Inhibition of IκB phosphorylation prevents load-induced cardiac dysfunction in mice.

  title={Inhibition of IκB phosphorylation prevents load-induced cardiac dysfunction in mice.},
  author={Tetsu Tanaka and Masahito Ogawa and Jun-Ichi Suzuki and Asuka Sekinishi and Akiko Itai and Yasunobu Hirata and Ryozo Nagai and Mitsuaki Isobe},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={303 12},
Pressure overload is known to be a cause of cardiac hypertrophy that often transits to heart failure. Although nuclear factor (NF)-κB is a key factor in the progression of cardiac hypertrophy, its pathophysiology is yet to be elucidated. Thus, we aimed to show that inhibition of NF-κB activation improves pressure overload-induced cardiac dysfunction. To assess the effect of inhibition on NF-κB activation in pressure overload cardiac hypertrophy, we used IMD-1041 in a murine thoracic aortic… CONTINUE READING
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