Inhibition of Hydrogen Sulfide Generation Contributes to 1-Methy-4-Phenylpyridinium Ion-Induced Neurotoxicity

@article{Tang2010InhibitionOH,
  title={Inhibition of Hydrogen Sulfide Generation Contributes to 1-Methy-4-Phenylpyridinium Ion-Induced Neurotoxicity},
  author={Xiao-Qing Tang and Li-li Fan and Yu-juan Li and Xin-Tian Shen and Yuan-Yuan Zhuan and Jian-qin He and Jin-hua Xu and Bi Hu and Yuanjian Li},
  journal={Neurotoxicity Research},
  year={2010},
  volume={19},
  pages={403-411}
}
Reactive oxygen species (ROS) overproduction contributes to the neurotoxicity of 1-methy-4-phenylpyridinium ion (MPP+). Increasing studies have shown that hydrogen sulfide (H2S) is an endogenous antioxidant gas. We have hypothesized that MPP+-caused neurotoxicity may involve the imbalance of proportion to this endogenous protective antioxidant gas. The aim of this study is to evaluate whether MPP+ disturbs H2S synthesis in PC12 cells, a clonal rat pheochromocytoma cell line, and whether… CONTINUE READING