• DOI:10.1213/01.ANE.0000062524.90936.1F
Corpus ID: 39630495

Inhibition of Human TREK-1 Channels by Bupivacaine

@article{Punke2003InhibitionOH,
  title={Inhibition of Human TREK-1 Channels by Bupivacaine},
  author={M. A. Punke and Thomas Licher and O. Pongs and P. Friederich},
  journal={Anesthesia & Analgesia},
  year={2003},
  volume={96},
  pages={1665–1673}
}

M. A. Punke, Thomas Licher, +1 author P. Friederich

Published 2003

Medicine

Anesthesia & Analgesia

Human TWIK-related K+ channels (TREK-1) stabilize the membrane potential (mp) of neurons and have a major role in the regulation of membrane excitability. In view of their physiological significance, interaction of bupivacaine with TREK-1 channels may be clinically important. Our aim was to characterize with the patch-clamp technique the properties of human TREK-1 channels and the effects of bupivacaine on these channels expressed in Chinese hamster ovary (CHO) cells. Transfection of CHO cells… CONTINUE READING

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