Inhibition of Human TREK-1 Channels by Bupivacaine

  title={Inhibition of Human TREK-1 Channels by Bupivacaine},
  author={M. A. Punke and Thomas Licher and O. Pongs and P. Friederich},
  journal={Anesthesia & Analgesia},
  • M. A. Punke, Thomas Licher, +1 author P. Friederich
  • Published 2003
  • Medicine
  • Anesthesia & Analgesia
  • Human TWIK-related K+ channels (TREK-1) stabilize the membrane potential (mp) of neurons and have a major role in the regulation of membrane excitability. In view of their physiological significance, interaction of bupivacaine with TREK-1 channels may be clinically important. Our aim was to characterize with the patch-clamp technique the properties of human TREK-1 channels and the effects of bupivacaine on these channels expressed in Chinese hamster ovary (CHO) cells. Transfection of CHO cells… CONTINUE READING
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