Inhibition of Human Cancer Cell Growth by 1,25-Dihydroxyvitamin D3 Metabolites1

Abstract

Specific high-affinity 1,25-dihydroxyvitamin D3 [1,25-{OH)2D3] receptors, which can undergo hormone-dependent activation and nuclear localization, have been demonstrated in a wide variety of established human cancer cell lines and surgically obtained human cancer tissues. 1,25-(OH)2D3 has been reported by some workers to stimulate cancer cell replication at… (More)

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