Inhibition of Host Vacuolar H+-ATPase Activity by a Legionella pneumophila Effector

@inproceedings{Xu2010InhibitionOH,
  title={Inhibition of Host Vacuolar H+-ATPase Activity by a Legionella pneumophila Effector},
  author={Li Xu and Xihui Shen and Andrew Bryan and Simran Banga and Michele S Swanson and Zhao-Qing Luo},
  booktitle={PLoS pathogens},
  year={2010}
}
Legionella pneumophila is an intracellular pathogen responsible for Legionnaires' disease. This bacterium uses the Dot/Icm type IV secretion system to inject a large number of bacterial proteins into host cells to facilitate the biogenesis of a phagosome permissive for its intracellular growth. Like many highly adapted intravacuolar pathogens, L. pneumophila is able to maintain a neutral pH in the lumen of its phagosome, particularly in the early phase of infection. However, in all cases, the… CONTINUE READING
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