Inhibition of Histo-blood Group Antigen Binding as a Novel Strategy to Block Norovirus Infections

@inproceedings{Zhang2013InhibitionOH,
  title={Inhibition of Histo-blood Group Antigen Binding as a Novel Strategy to Block Norovirus Infections},
  author={Xu-fu Zhang and Ming Tan and Monica Chhabra and Ying-chun Dai and Jarek Meller and Xi Jiang},
  booktitle={PloS one},
  year={2013}
}
Noroviruses (NoVs) are the most important viral pathogens that cause epidemic acute gastroenteritis. NoVs recognize human histo-blood group antigens (HBGAs) as receptors or attachment factors. The elucidation of crystal structures of the HBGA-binding interfaces of a number of human NoVs representing different HBGA binding patterns opens a new strategy for the development of antiviral compounds against NoVs through rational drug design and computer-aided virtual screening methods. In this study… CONTINUE READING

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