Inhibition of High-conductance, Calcium-activated Potassium Channels of Rabbit Colon Epithelium by Magnesium

@article{Wachter1996InhibitionOH,
  title={Inhibition of High-conductance, Calcium-activated Potassium Channels of Rabbit Colon Epithelium by Magnesium},
  author={Christoph Wachter and Klaus Turnheim},
  journal={The Journal of Membrane Biology},
  year={1996},
  volume={150},
  pages={275-282}
}
High-conductance, Ca2+-activated K+ channels from the basolateral membrane of rabbit distal colon epithelial cells were reconstituted into planar phospholipid bilayers to examine the effect of Mg2+ on the single-channel properties. Mg2+ decreases channel current and conductance in a concentration-dependent manner from both the cytoplasmic and the extracellular side of the channel. In contrast to other K+ channels, Mg2+ does not cause rectification of current through colonic Ca2+-activated K… CONTINUE READING