Inhibition of Hes1 activity in gall bladder epithelial cells promotes insulin expression and glucose responsiveness.

@article{Coad2009InhibitionOH,
  title={Inhibition of Hes1 activity in gall bladder epithelial cells promotes insulin expression and glucose responsiveness.},
  author={Ross A Coad and James R Dutton and David. Tosh and Jonathan M. W. Slack},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  year={2009},
  volume={87 6},
  pages={975-87}
}
The biliary system has a close developmental relationship with the pancreas, evidenced by the natural occurrence of small numbers of biliary-derived beta-cells in the biliary system and by the replacement of biliary epithelium with pancreatic tissue in mice lacking the transcription factor Hes1. In normal pancreatic development, Hes1 is known to repress endocrine cell formation. Here we show that glucose-responsive insulin secretion can be induced in biliary epithelial cells when activity of… CONTINUE READING