Inhibition of Hepatitis C Virus Replication and Viral Helicase by Ethyl Acetate Extract of the Marine Feather Star Alloeocomatella polycladia

  title={Inhibition of Hepatitis C Virus Replication and Viral Helicase by Ethyl Acetate Extract of the Marine Feather Star Alloeocomatella polycladia},
  author={Atsuya Yamashita and Kazi Abdus Salam and Atsushi Furuta and Yasuyoshi Matsuda and Osamu Fujita and Hidenori Tani and Yoshihisa Fujita and Yuusuke Fujimoto and Masanori Ikeda and Nobuyuki Kato and Naoya Sakamoto and Shinya Maekawa and Nobuyuki Enomoto and Masamichi Nakakoshi and Masayoshi Tsubuki and Yuji Sekiguchi and Satoshi Tsuneda and Nobuyoshi Akimitsu and Naohiro Noda and Junichi Tanaka and Kohji Moriishi},
  journal={Marine Drugs},
  pages={744 - 761}
Hepatitis C virus (HCV) is a causative agent of acute and chronic hepatitis, leading to the development of hepatic cirrhosis and hepatocellular carcinoma. We prepared extracts from 61 marine organisms and screened them by an in vitro fluorescence assay targeting the viral helicase (NS3), which plays an important role in HCV replication, to identify effective candidates for anti-HCV agents. An ethyl acetate-soluble fraction of the feather star Alloeocomatella polycladia exhibited the strongest… 

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