Inhibition of Hepatitis B Virus and Induction of Hepatoma Cell Apoptosis by ASGPR-Directed Delivery of shRNAs

@inproceedings{Ma2012InhibitionOH,
  title={Inhibition of Hepatitis B Virus and Induction of Hepatoma Cell Apoptosis by ASGPR-Directed Delivery of shRNAs},
  author={Jingwei Ma and Chunmei Huang and Xinxin Yao and Chuan Shi and Lifang Sun and Lu Yuan and Ping Han Lei and Huifen Zhu and Hongbo Liu and Xiongwen Wu and Xiaoyang Wan and Chun Zhou and Guanxin Shen},
  booktitle={PloS one},
  year={2012}
}
Hepatitis B virus (HBV) infection is a worldwide liver disease and nearly 25% of chronic HBV infections terminate in hepatocellular carcinoma (HCC). Currently, there is no effective therapy to inhibit HBV replication and to eliminate hepatoma cells, making it highly desired to develop novel therapies for these two stages of the HBV-caused detrimental disease. Recently, short hairpin RNA (shRNA) has emerged as a potential therapy for virus-infected disease and cancer. Here, we have generated a… CONTINUE READING