Inhibition of Helicobacter pylori adhesion to Kato III cells by intact and low molecular weight acharan sulfate

@article{Sim2011InhibitionOH,
  title={Inhibition of Helicobacter pylori adhesion to Kato III cells by intact and low molecular weight acharan sulfate},
  author={Joon-Soo Sim and Bum-Soo Hahn and A-Rang Im and Youmie Park and Ji-eun Shin and Eun-Ah Bae and Dong-Hyun Kim and Yeong Shik Kim},
  journal={Glycoconjugate Journal},
  year={2011},
  volume={28},
  pages={411-418}
}
We investigated the inhibitory activity of glycosaminoglycans (GAGs) in terms of growth, adhesion, and VacA vacuolation of Helicobacter pylori. Intact acharan sulfate (AS, MW:114 kDa) potently inhibited H. pylori adhesion to Kato III cells with IC50 value of 1.4 mg/mL, while other GAGs did not show any inhibitory activity except for heparin which is a well-known inhibitor of H. pylori adhesion. To investigate whether low molecular weight acharan sulfate (LMWAS) can inhibit H. pylori adhesion… CONTINUE READING