Inhibition of Helicobacter hepaticus-induced colitis by IL-10 requires the p50/p105 subunit of NF-kappa B.

@article{Tomczak2006InhibitionOH,
  title={Inhibition of Helicobacter hepaticus-induced colitis by IL-10 requires the p50/p105 subunit of NF-kappa B.},
  author={Michal F. Tomczak and Susan E. Erdman and Anne Davidson and Yan Yan Wang and Prashant R Nambiar and Arlin B. Rogers and Barry Rickman and David G Luchetti and James G Fox and Bruce H Horwitz},
  journal={Journal of immunology},
  year={2006},
  volume={177 10},
  pages={7332-9}
}
Defects within the innate immune system sensitize NF-kappaB-deficient (p50(-/-); p65(+/-)) mice to Helicobacter hepaticus (Hh)-induced colitis. Because IL-10 plays a central role in the inhibition of Hh-induced colitis, we hypothesized that the ability of IL-10 to inhibit the innate inflammatory response to Hh may be compromised in NF-kappaB-deficient mice. To test this hypothesis, we evaluated the ability of an IL-10-Ig fusion protein with IL-10-like properties to inhibit Hh-induced colitis in… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Nuclear Factor-Kappa-B Signaling in Lung Development and Disease: One Pathway, Numerous Functions

Birth defects research. Part A, Clinical and molecular teratology • 2014
View 1 Excerpt

Similar Papers

Loading similar papers…