Inhibition of HSP90 by AUY922 Preferentially Kills Mutant KRAS Colon Cancer Cells by Activating Bim through ER Stress.

@article{Wang2016InhibitionOH,
  title={Inhibition of HSP90 by AUY922 Preferentially Kills Mutant KRAS Colon Cancer Cells by Activating Bim through ER Stress.},
  author={Chun Yan Wang and Su Tang Guo and Jia Yu Wang and Fen Liu and Yuan Zhang and Hamed Yari and Xu Guang Yan and Lei Jin and Xu Dong Zhang and Chen Chen Jiang},
  journal={Molecular cancer therapeutics},
  year={2016},
  volume={15 3},
  pages={448-59}
}
Oncogenic mutations of KRAS pose a great challenge in the treatment of colorectal cancer. Here we report that mutant KRAS colon cancer cells are nevertheless more susceptible to apoptosis induced by the HSP90 inhibitor AUY922 than those carrying wild-type KRAS. Although AUY922 inhibited HSP90 activity with comparable potency in colon cancer cells irrespective of their KRAS mutational statuses, those with mutant KRAS were markedly more sensitive to AUY922-induced apoptosis. This was associated… CONTINUE READING
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