Inhibition of HMG CoA reductase reveals an unexpected role for cholesterol during PGC migration in the mouse

@article{Ding2008InhibitionOH,
  title={Inhibition of HMG CoA reductase reveals an unexpected role for cholesterol during PGC migration in the mouse},
  author={Jiaxi Ding and Dechen Jiang and Michael E. Kurczy and Jennifer L Nalepka and Brian M. Dudley and Erin I Merkel and Forbes D Porter and Andrew G Ewing and Nicholas Winograd and James D Burgess and Kathleen Molyneaux},
  journal={BMC Developmental Biology},
  year={2008},
  volume={8},
  pages={120 - 120}
}
Primordial germ cells (PGCs) are the embryonic precursors of the sperm and eggs. Environmental or genetic defects that alter PGC development can impair fertility or cause formation of germ cell tumors. We demonstrate a novel role for cholesterol during germ cell migration in mice. Cholesterol was measured in living tissue dissected from mouse embryos and was found to accumulate within the developing gonads as germ cells migrate to colonize these structures. Cholesterol synthesis was blocked in… CONTINUE READING
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