Inhibition of HIV replication by amino-sugar derivatives.

  title={Inhibition of HIV replication by amino-sugar derivatives.},
  author={George W J Fleet and Abraham Karpas and Raymond A. Dwek and L. E. Fellows and A Stanley Tyms and Sigurdur R Petursson and Sung Keon Namgoong and Nigel Ramsden and Paul W Smith and Jong Chan Son},
  journal={FEBS letters},
  volume={237 1-2},
The plant alkaloids castanospermine, dihydroxymethyldihydroxypyrrolidine and deoxynojirimycin have recently been shown to have potential anti-HIV activity [(1987) Proc. Natl. Acad. Sci. USA 84, 8120-8124; (1987) Nature 330, 74-77; (1987) Lancet i, 1025-1026]. They are thought to act by inhibiting alpha-glucosidase I, an enzyme involved in the processing of N-linked oligosaccharides on glycoproteins. We report here the relative efficacy of a spectrum of amino-sugar derivatives as inhibition of… CONTINUE READING