Inhibition of HIV replication and macrophage colony-stimulating factor production in human macrophages by antiretroviral agents.

@article{Kutza2002InhibitionOH,
  title={Inhibition of HIV replication and macrophage colony-stimulating factor production in human macrophages by antiretroviral agents.},
  author={Joseph Kutza and Karen Fields and Tobias Alexander Grimm and Kathleen A. Clouse},
  journal={AIDS research and human retroviruses},
  year={2002},
  volume={18 9},
  pages={619-25}
}
Macrophage colony-stimulating factor (M-CSF) enhances the susceptibility of macrophages to infection with HIV-1, in part by increasing the expression of CD4 and CCR5. Human monocyte-derived macrophages (MDMs) infected in vitro with HIV-1 endogenously produce M-CSF, with kinetics paralleling virus replication, which can lead to enhanced spreading of the infection. AZT and ritonavir both inhibit HIV replication, but their impact on M-CSF production by HIV-infected human MDMs is unknown. The dose… CONTINUE READING