Inhibition of HIV infection by flavanoids.

  title={Inhibition of HIV infection by flavanoids.},
  author={Naheed Mahmood and Cosimo P{\`i}zza and R. C. Aquino and Nunziatina De Tommasi and Sonia Piacente and Silvie Colman and Andy Burke and Alan J. Hay},
  journal={Antiviral research},
  volume={22 2-3},
Of a variety of flavanoids, the flavans were generally more effective than flavones and flavanones in selective inhibition of HIV-1, HIV-2 or SIV infection. Studies of their effects on the binding of sCD4 and antibody to gp120 indicated that the effective compounds interact irreversibly with gp120 to inactive virus infectivity and block infection.