Inhibition of HIV-1 replication in lymphocytes by mutants of the Rev cofactor eIF-5A.

@article{Bevec1996InhibitionOH,
  title={Inhibition of HIV-1 replication in lymphocytes by mutants of the Rev cofactor eIF-5A.},
  author={Dorian Bevec and Hans Jaksche and M Oft and Thorsten W{\"o}hl and Mich{\`e}le Himmelspach and A. P{\^a}cher and Michael Schebesta and K Koettnitz and Michael Dobrovnik and Robert Csonga and Friedrich Lottspeich and Joachim Hauber},
  journal={Science},
  year={1996},
  volume={271 5257},
  pages={1858-60}
}
Eukaryotic initiation factor 5A(eIF-5A) is a cellular cofactor require d for the function of the human immunodeficiency virus type-1 (HIV-1) Rev trans-activator protein. The majority of a set of eIF-5A mutants did not support growth of yeast cells having an inactivated genomic copy of eIF-5A, indicating that the introduced mutation eliminated eIF-5A activity. Two nonfunctional mutants, eIF-5AM13 and eIF-5AM14, retained their binding capacity for the HIV-1 Rev response element:Rev complex. Both… CONTINUE READING

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