Inhibition of HIV-1 replication by the combined action of anti-gp41 single chain antibody and IL-16.

@article{Devadas2003InhibitionOH,
  title={Inhibition of HIV-1 replication by the combined action of anti-gp41 single chain antibody and IL-16.},
  author={Krishnakumar Devadas and Paul Zhou and Deepanker Tewari and Abner Louis Notkins},
  journal={Antiviral research},
  year={2003},
  volume={59 1},
  pages={67-70}
}
HIV-1 replication is inhibited in T cells transfected with an anti-gp41 single chain antibody (ScFv) or IL-16. These two molecules target totally different events in the HIV-1 replication cycle. The present study shows that HIV-1 replication is inhibited to a substantially greater extent and for a longer duration in cells transfected with both anti-gp41 and IL-16 than with either molecule alone. It is concluded that anti-gp41 and IL-16 act in a synergistic fashion to inhibit HIV-1 replication. 

Topics