Inhibition of HIV-1 replication by cyclopentenone prostaglandins in acutely infected human cells. Evidence for a transcriptional block.

@article{Rozera1996InhibitionOH,
  title={Inhibition of HIV-1 replication by cyclopentenone prostaglandins in acutely infected human cells. Evidence for a transcriptional block.},
  author={Carmela Rozera and Alessandra Carattoli and A de Marco and Carla Amici and Carlotta Giorgi and Maria Gabriella Santoro},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={97 8},
  pages={1795-803}
}
Cyclopentenone prostaglandins (PGs) inhibit virus replication in several DNA and RNA virus models, in vitro and in vivo. In the present report we demonstrate that the cyclopentenone prostaglandins PGA(1) and PGJ(2) at nontoxic concentrations can dramatically suppress HIV-1 replication during acute infection in CEM-SS cells. PGs did not affect HIV-1 adsorption, penetration, reverse transcriptase activity nor viral DNA accumulation in HIV-1 infected cells. A dramatic reduction in HIV-1 mRNA… CONTINUE READING

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Virus infection. In Stress-Inducible Cellular Responses

  • M. G. Santoro
  • Birkhauser Verlag, Basel-Boston-Berlin
  • 1996

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