Inhibition of HIV-1 integrase nuclear import and replication by a peptide bearing integrase putative nuclear localization signal

@inproceedings{Levin2009InhibitionOH,
  title={Inhibition of HIV-1 integrase nuclear import and replication by a peptide bearing integrase putative nuclear localization signal},
  author={Aviad Levin and Ayelet Armon-Omer and Joseph Rosenbluh and Naomi Melamed-Book and A. Graessmann and Elisabeth Waigmann and Abraham Loyter},
  booktitle={Retrovirology},
  year={2009}
}
The integrase (IN) of human immunodeficiency virus type 1 (HIV-1) has been implicated in different steps during viral replication, including nuclear import of the viral pre-integration complex. The exact mechanisms underlying the nuclear import of IN and especially the question of whether it bears a functional nuclear localization signal (NLS) remain controversial. Here, we studied the nuclear import pathway of IN by using multiple in vivo and in vitro systems. Nuclear import was not observed… CONTINUE READING

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