Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A

@article{Hoque2009InhibitionOH,
  title={Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A},
  author={Mainul Hoque and Hartmut M. Hanauske-Abel and Paul E. Palumbo and Deepti Saxena and Darlene D'Alliessi Gandolfi and Myung Hee Park and Tsafi Pe'ery and Michael B. Mathews},
  journal={Retrovirology},
  year={2009},
  volume={6},
  pages={90 - 90}
}
Eukaryotic translation initiation factor eIF5A has been implicated in HIV-1 replication. This protein contains the apparently unique amino acid hypusine that is formed by the post-translational modification of a lysine residue catalyzed by deoxyhypusine synthase and deoxyhypusine hydroxylase (DOHH). DOHH activity is inhibited by two clinically used drugs, the topical fungicide ciclopirox and the systemic medicinal iron chelator deferiprone. Deferiprone has been reported to inhibit HIV-1… CONTINUE READING
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